The 375th Medical Group supports the 375th Air Mobility Wing and 66 associate units including USTRANSCOM, AMC, SDDC, AFNIC, 18th AF and 174 GSUs in the global reach mission by providing, expanding, and deploying medical capability for contingency taskings. The medical group trains 60 personnel annually through four specialty training programs and sustains the readiness skills of more than 850 active duty and Air Reserve Component personnel. In addition to the medical group's readiness mission, it provides health services for more than 60,000 local beneficiaries and 1,500 aeromedical patients. The medical group is accredited by the Accreditation Association for Ambulatory Health Care, American Dental Association, and College of American Pathologists and has affiliations with the American Hospital Association, and American Medical Association. The group is comprised of four squadrons:

The 375th Aerospace Medicine Squadron enables combat power through disease prevention, medical intervention, occupational and environmental health programs and preparation for medical contingencies. A staff of more than 100 Air Force healthcare professionals organized into six flights provide flight medicine services to nearly 1,500 rated personnel and their families, preventive integrated health care through public health, bioenvironmental engineering, optometry and health and wellness center activities for 60,000 beneficiaries and coordinates aeromedical staging transfer and care for injured and wounded military members from all Armed Services.

The 375th Medical Operations Squadron (MDOS) provides comprehensive primary care and limited referral and space-available subspecialty care to more than 60,000 TRICARE enrolled patients empanelled at the medical group and in the civilian network. The squadron also has responsibility for the Family Medicine Training Program, which is a joint civilian-military residency program sponsored by the Saint Louis University School of Medicine Family Practice Program. The squadron is comprised of eight flights: Scott Primary Care Clinic, Family Medicine, Medical Services, Mental Health, Physical Medicine, Obstetrics/Gynecology and Diagnostic Imaging. They have a combined strength of nearly 400 assigned personnel. Available services include: dermatology, family advocacy, family medicine, mental health, pediatrics, primary care and substance abuse counseling. Combined, these clinics average more than 12,000 patient visits per month totaling almost 148,000 visits per year. The 375th Medical Support Squadron (MDSS) consists of ten flights providing personnel and administration, resource management, education and training, TRICARE Operations and Patient Administration, medical readiness, information management, pharmacy, laboratory, nutritional medicine and logistics which includes: regional medical equipment repair, patient movement items and facility management. The 375 MDSS supports healthcare delivery by managing a group budget of $34 million dollars as of June 2009 and manpower programs for more than 700 staff members. The managed care program supports an enrolled population of more than 26,000 with more than 135,000 annual patient visits. Additionally, the squadron provides ancillary services with a $12 million dollar pharmacy budget and laboratory services with an average of more than 120 patients daily.

The 375th Dental Squadron (DS) provides a full range of dental services for active duty military members including general dentistry, endodontics, oral and maxillofacial surgery, orthodontics, periodontics and prosthodontics. The squadron also supports an Advanced Education in General Dentistry Residency Program. Families of active duty 375th Medical Group military are highly encouraged to enroll in the TRICARE Dental Program to obtain dental care from civilian dentists, as space-available dependent care is extremely limited. Likewise, dental care for retired military and their family members is very limited and only available on a space available basis.