The 375th Airlift Wing makes possible the command and control of the United States' entire military transportation effort— the logistics efforts of the world's greatest military in the air, on the ground and over the sea. Together, we execute every Air Mobility Command sortie worldwide, in peace and in war. When the people or cargo is of the highest priority, we provide the global mobility ourselves in C-21s. When lives hang in the balance, we provide aeromedical evacuation worldwide. The same incredible Airmen who make Global Mobility happen at home station become combat-ready expeditionary forces for combatant commanders worldwide.

At home station, the 375th AW is comprised of several staff agencies and four groups: the 375th Medical Group, 375th Operations Group, 75th Mission Support Group and 375th Communications Group.

The 375th AW's operational support aircraft fleet consists of C-21A Learjets stationed here and at two geographically separated units around the country.

The OSA missions, which are centrally scheduled by U.S. Transportation Command, provide transportation for government officials and cargo requiring time-sensitive airlift.

As the host unit, the 375th AW supports four major headquarters and a numbered air force with worldwide responsibilities: U.S. Transportation Command, 18th Air Force, Air Mobility Command, the Surface Deployment Distribution Command and the Defense Information Technology Systems Agency. It also provides support for the Air Force Communications Agency, the Defense Information Technology Contracting Office, the 932nd Airlift Wing (Reserve) and the Illinois Air National Guard's 126th Air Refueling Wing—along with approximately 66 other associate partner units.

Together, the 375th AW is the center of excellence and Air Mobility Command's Showcase Wing—Making Global Mobility Happen.