The Commanding General leads the Maneuver Support Center (MANSCEN) at Fort Leonard Wood which creates Warriors and develops Leaders and capabilities that assure the mobility, freedom of action and protection of the forces they support. The Commandants of the United States Army Chemical, Biological, Radiological and Nuclear School (USACBRNS); United States Army Engineer School (USAES); and the United States Army Military Police School (USAMPS); are Deputies to the Commanding General for the following areas, respectively: Materiel and Technology; Concepts, Doctrine, and Organizations; and Training and Leader Development. The resident General Officers for the United States Army Reserve and National Guard also serve as Deputies to the Commanding General. MANSCEN also has a Senior Executive Service Deputy to the Commanding General with oversight of the Directorate of Training, Capabilities Development and Integration Directorate and the Program Management and Integration Directorate. The Command Sergeant Major, senior noncommissioned officer of MANSCEN, serves as the senior enlisted advisor to the Commanding General on policy matters pertaining to MANSCEN enlisted soldiers, individual skills and training. The Chief of Staff is the principal coordinating agent for the MANSCEN regarding day-to-day operations and relationships with higher, adjacent, subordinate and supported units, agencies and activities. The Secretary of the General Staff (SGS) office advises MANSCEN senior leaders and installation staff on all matters relating to command policy, administration and protocol. The SGS also provides administrative, personnel and logistical support to the MANSCEN Command Element; coordinates and executes all dignitary visits to the installation; provides coordination and support for all protocol activities; and provides speech writing services for the Command Element.

The Program Management and Integration Directorate is the Maneuver Support Center of Excellence's centralized manager responsible for the integration and synchronization of MANSCEN doctrine, organization, training, material, leadership and education, personnel and facilities (DOTMLPF) capability developments among several entities. These are Capabilities Development Integration Directorate (CDID), MANSCEN Directorate of Training (MDoT), Schools and Garrison Staff in order to deliver maneuver support capability to the Army. Inherent to this is to sustain a continuous DOTMLPF capability gap analysis and solution process based on priorities of the center, school commandants and realities of war and other deployed operations. The Directorate is divided into three major sections, the TRADOC Capability Manager-Maneuver Support (TCM-MS), the MANSCEN Knowledge Management (KM) Office and the Joint, Interagency and Multinational (JIM). TCM-MS executes the PMID mission as the DOTMLPF program manager and integrates all developmental programs associated with functional and multi-functional capabilities to assure the mobility, freedom of action, and protection of Army units in full spectrum operations. The Knowledge Management Office provides state-of-the-art access to knowledge building and sharing opportunities for the MANSCEN workforce and customers. They foster daily collaboration among stakeholders combined with leveraged technology to facilitate a learning-focused culture. The focus of the JIIM section is the integration of planning and staff coordination to ensure interagency, intergovernmental and multinational aspects are synchronized with MANSCEN capability developments process.