The unit was constituted into the Regular Army on Jan. 18, 1966, as the 43rd General Support Group. The unit was activated on March 26, 1966, at Fort Carson and organized on May 16, 1966. The first battalion to join the group was the 68th Transportation Battalion which was activated in August 1966. Three more battalions joined the Group in 1967: 195th Maintenance Battalion on Feb. 23; 242nd Maintenance Battalion on Feb. 25; and 70th Ordnance Battalion on March 1.
On July 26, 1967, acting on a seven-hour notification, Headquarters and Headquarters Company, 43rd and 352nd Transportation Company (Light Truck) deployed to Selfridge Air Force Base, Michigan, to provide logistical support for the elements of the XVIII Airborne Corps during riot control operations. In August and September 1967, units of the group deployed to Alaska during severe flooding to establish a field laundry site. In 1968, the organization of the group changed: the 336th Ordnance Battalion joined the group May 20 and the 242nd Maintenance Battalion, one of the group’s original members, inactivated Aug. 25. In addition to group organization changes, the 336th Ordnance Battalion deployed to Southeast Asia Sept. 26, 1968.
In 1970, three military police companies (19th, 148th and 984th) and the 283rd Aviation Company joined the group in May; the 40th Supply and Service Company joined the group in November; and the 195th Maintenance Battalion (another of the group’s original members) inactivated Dec. 4. In 1971, the 283rd Aviation Company was transferred to Fort Bragg, North Carolina in June; the 4th Military Police Company joined the group; and a third original member, the 70th Ordnance Battalion, was inactivated in November. In 1972, the 19th Military Police Battalion was formed as a headquarters for the Military Police companies; the 52nd Engineer Battalion joined the group in July; and the 4th Military Intelligence Company and Company B, 75th Infantry (Ranger) joined the group in August. The group was redesignated as the 43rd Corps Support Group in 1973.
The 43rd served in operations Desert Shield and Desert Storm; Operation Continue Hope; operation Sea Signal; Operation Iraqi Freedom; and Operation Enduring Freedom.
Effective July 17, 2008, the 43rd Area Support Group was redesignated as the 43rd Sustainment Brigade. As part of the reorganization, the 43rd Brigade Special Troops Battalion and 230th Financial Management Company (FMCO) were activated and the 10th Combat Support Hospital and 4th Engineer Battalion were reassigned away from the brigade.
The 43rd Sustainment Brigade was redesignated the 4th Sustainment Brigade, 4th Infantry Division, effective July 9, 2015. As part of the reorganization, 4th Sustainment Brigade integrated fully into the overall 4th Infantry Division command at Fort Carson to continue the outstanding support for 4th Infantry Division and Fort Carson Soldiers.